Introduction to Talmud Study

I'm about to begin studiying Talmud for the first time, but heard that its setup is a bit complicated. Before I begin, are there any books in English that you can recommend as preparation?

I suggest the following books:

ArtScroll Schottenstein Edition has an excellent introductory volume.
The Oral Law by Harry C. Schimmel is a fantastic book.
There is also an English translation of R. Zvi Hirsch Chiyus (Chajes) "Student's Guide Through the Talmud"

Good luck with your studies.